The first transatlantic flight powered only by alternative fuels is due to take off on Tuesday, the BBC reports.
Operated by Virgin Atlantic, it will fly from London’s Heathrow to New York’s JFK airport at 11:30 GMT.
Airlines see the flight, which is supported by government funding, as demonstrating that a greener way of flying is possible.
But a lack of supply remains a challenge, while other technology will be needed to hit emissions targets.
So-called sustainable aviation fuels (SAF) can be made from a variety of sources, including crops, household waste and cooking oils.
For this flight, a Boeing 787 will be filled with 50 tonnes of SAF. Two types are being used, with 88% derived from waste fats and the rest from the wastes of corn production in the US.
Following test and analysis, the flight was approved by UK regulator the Civil Aviation Authority earlier this month. A number of companies have been involved in the project including engine-maker Rolls-Royce and energy giant BP.
The aviation industry is particularly difficult to decarbonize, but airline bosses view SAF as the most effective tool available to help bring its net emissions down to zero.