Dutch Prince Johan Friso has died after a year and a half in a coma following an accident at an Austrian ski resort, the BBC reports.
Prince Friso, who was 44, was moved from hospital in London back to the Netherlands last month, but had since suffered complications.
He was hit by an avalanche in February 2012 and buried for 15 minutes.
King Willem-Alexander and Queen Maxima are said to be on their way home from a holiday in Greece.
“Prince Friso has died of complications related to the hypoxic brain injury, which he suffered as the result of his skiing accident in Lech, Austria on 17 February 2012,” a royal palace statement said.
He died on Monday morning in The Hague, the palace added.
The prince’s wife, Princess Mabel, is said to have spent her 45th birthday on Sunday at his bedside.