US President Donald Trump is due to hold talks with Pope Francis and Italy’s top leaders in Rome on the third leg of his first oversees trip, the BBC reports.
Mr Trump and the pontiff have already clashed at a distance on issues including migration and climate change.
Mr Trump will also meet Italy’s president and prime minister, before flying to Brussels for a Nato summit.
He earlier vowed to help Israelis and Palestinians achieve peace, as he ended the Middle East leg of his tour.
The US leader began his foreign trip with a two-day stop in Saudi Arabia over the weekend, urging Muslim countries to take the lead in combating radicalisation.