US President Joe Biden and his Russian counterpart Vladimir Putin are meeting for their first, highly-anticipated summit, the BBC reports.
The talks in Geneva, Switzerland, come at a time when both sides describe relations as being at rock bottom.
Discussions are set to include arms control and US allegations of Russian cyber-attacks.
No major breakthroughs are expected but there are hopes of finding small areas of agreement.
The meeting comes on the tail end of Mr Biden’s first foreign trip as US president, in which he has also attended meetings with G7 and Nato leaders. Going into the summit, Mr Biden has stressed that he has the backing of his Western partners.
The choice of Geneva as the setting harks back to the Cold War summit between US President Ronald Reagan and Soviet leader Mikhail Gorbachev in 1985.
Neither the US nor Russia currently has an ambassador in-country, and Russia recently included the US on its official list of “unfriendly states”.
However, Mr Biden has said the meeting is an important step if they are to ultimately find “stability and predictability” in relations, while Mr Putin told state TV there were “issues where we can work together”.
But Yuri Ushakov, Mr Putin’s foreign affairs adviser, told journalists there was “not much” ground for optimism, while Kremlin spokesman Dmitry Peskov said the talks would be “very difficult”.
Ushakov said the issue of Nagorno Karabakh would also be on the agenda