An EgyptAir flight from Paris to Cairo has disappeared from radar, the Egyptian airline says, the BBC reports.
It says there are 56 passengers, seven crew members and three security personnel on board Flight MS804.
The Airbus A320 was flying at 37,000ft (11,300m) when it went missing over the eastern Mediterranean. An official said the plane lost contact with radar at 02:45 Cairo time (00:45 GMT).
EgyptAir says search and rescue teams have been deployed.
EgyptAir has just a tweet confirming the nationalities of the passengers.
There are 15 French, 30 Egyptian, one Briton, one Belgian, two Iraqis, one Kuwaiti, one Saudi, one Sudanese, one Chadian, one Portuguese, one Algerian and one Canadian.