William Hague has stood down as foreign secretary, but will stay in the cabinet as Leader of the Commons, Downing Street has said, the BBC reports.
There will be at least 12 men leaving their posts in the significant ministerial reshuffle.
Labour described the reshuffle as “the massacre of the moderates”.
Mr Hague is to leave Parliament at the 2015 general election after 26 years as MP for Richmond, North Yorkshire.
Senior ministers have told the BBC that the current defence secretary, Philip Hammond, will replace Mr Hague.